ZAISMA-200mg
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Introduction
ZAISMA-200 mg (Udenafil) which is used to treat erectile
dysfunction (ED) in men, the trade name of Udenafilstimulation dosage5, 10 and mg
once daily. As a PDE5 inhibitor, it works to improve blood flow in the penis at the time of intimacy stimulation helping men get and keep an erection. The above
picture would have explained that Norvasc interferes with the vasodilatory
abilities of Viagra (and the other PDE-5 inhibitors) - decreasing erectile
responses and Udenafil, a PDE-5 inhibitor increases cGMP so you get more of an
erection for longer.
How It Works zaisma-200mg:
Zaisma 200 mg Udenafil
inhibits phosphodiesterase type 5, an enzyme that degrades cyclic guanosine
monophosphate (cGMP) in cavernous smooth muscle cells and PDE3 is present in
the heart and blood vessels. How does Levitra work to treat erectile dysfunction:
Levitra 20mg tablet helps relax and expand the blood vessels in your penis,
allowing for more blood flow - resulting an erection after intimacy stimulation.
And this results in the surrender of the crammed muscles and improves blood stream
over penile tissues which subsequently causes an erection.
Dosage and Administration:
Recommended First Dose
(Watch): Take a 50 mg tablet orally approximately thirty minutes to one hour
before physical activity. Dose Adjustment - The dose may be adjusted according to
efficacy and tolerability. But do not use more than 200 mg of Vitamin B5 a day
as the highest recommended dosage. Dosage: 200mg PO Administered with or
Without Food It must be ingested whole with a glass full of water.
Pharmacokinetics
Absorption: Following oral administration, udenafil is
rapidly absorbed with an average time to maximum plasma concentration (max) of
less than 1-2 hours.
It has a wide distribution throughout the body - high VD.
Enzymes: Zaisma-200 mg Udenafil is metabolized
predominantly by hepatic liver enzymes, such as the CYP3A4 enzyme.
Elimination:
conjugated metabolites and
unchanged drugs are excreted in the faces; about 20% is found in urine. Udenafil
has a half-life of 11-13 hours as efficiently.
Side Effects Common side effects include:
Headache Flushing Nasal Congestion Dyspepsia (indigestion)
Dizziness Mild side effects occur, but less common and serious: Priapism
(prolonged erection) Sudden hearing loss Visual disturbances
Contraindications ZAISMA-200 mg
Udenafil, or any component of the tablet. Acute CVD (e.g., new MI/
stroke) Grade 3 uncontrolled hypertension with mild hypotension They are
contraindicated with nitrates or nitric oxide donors because of a risk for
severe hypotension.
Geriatric:
Use caution and start at the low end of the dosing range; the elderly may
have increased sensitivity to the drug, but dosage modifications are generally not
required IN RENAL INSUFFICIENCY it is the subject of clinical study & with
this dose adjustment data are not needed in mild to moderate renal
insufficiency. Caution in case of severe impairment Hepatic Impairment: Use is
not recommended for patients with hepatic impairment, based on a clinical
study.
Clinical Trials
Many clinical trials have been conducted to evaluate the safety
and efficacy of Udenafil for treating erectile dysfunction. These studies confirm that Udenafil is an effective and secure drug to have a good
improvement in erectile function. Main trials are randomized, double-blind, and
placebo-controlled studies in various populations.
Conclusion:
What is ZAISMA-200 mg (Udenafil) ZAISMA, an oral medication known as Udenafil treats erectile dysfunction in men with significant advantages and facilitates patients to enhance their physical health. Udenafil not only has an acceptable safety profile but also it is efficacious and provides another valuable alternative in the management of ED. Long-term research and data from real-world practice keep on benefitting it, while broader indications for its use could hopefully be derived in future studies.
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