TRETIVA 5 MG
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$2.75
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$2.75
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$2.75
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$2.75
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Introduction
Tretiva is primarily used to treat scarring from cystic acne or severe acne that has not fully responded to various treatment. Isotretinoin is the active ingredient in Tretiva, a potent vitamin A-derived retinoid that reduces sebaceous oil production and the size of these glands. While this medication is a potent treatment for severe, nodular, or cystic acne, it has a wide side effect profile, making careful monitoring and follow-up by healthcare professionals essential.
Clinical Uses
Tretiva 5 mg is primarily prescribed for:
- Moderate
to severe nodular acne: When other treatments, such as antibiotics, are ineffective.
- Intractable acne: Acne that does not respond to traditional treatments.
- Off-label Uses: Isotretinoin may be used in less common situations, typically managed by dermatology specialist.
Dosage and Administration
- Initial Dose: The usual starting dose of Tretiva is 0.5 to 1 mg/kg/day, divided into two doses taken with food to enhance absorption.
- Dosing: Dose adjustments may be necessary based on individual tolerability and response. Normally a cumulative dose of 120 to 150 mg/kg is suggested to decrease relapse rates.
- Time Requirement: Treatment typically lasts 15-20 weeks, although this may vary depending on the severity of acne scarring and the patient's response to treatment.
- Monitoring: Regular monitoring of the patient's response to the medication is essentia.
Efficacy
Multiple clinical trials have demonstrated that isotretinoin is highly effective against severe acne. Most patients reported improvement within the first two months, achieving complete therapeutic benefits by the end of the treatment course. Most patients remain in remission with long-term follow-up, although some may require another course of therapy.
Side Effects
Common and Serious Side Effects: Isotretinoin has several common side effects, as well as some very severe ones:
- Common adverse reactions include dry skin, chapped lips, dry eyes, nosebleeds, and increased sensitivity to sunlight. The occurrence of these side effects depends on the dose, and they are generally reversible after discontinuatio.
- Significant Side Effects: At high doses, significant side effects may include birth defects, increased lipid levels in the bloodstream (a risk factor for cardiovascular disease), liver function disorders, depression, and possibly inflammatory bowel disease. Due to these risks, isotretinoin is generally reserved for patients with severe acne who have not responded to other treatments.
Psychiatric Effects
Case reports have described depression, psychosis, and rare instances of suicidal ideation among isotretinoin users. Patients must be monitored for increases in mood or behavioral symptoms and promptly advised to report any changes to their healthcare providers. In some cases, discontinuation of the medication may be necessary.
Normal HIV viral load, Liver
Function, and Lipids Levels
Isotretinoin can elevate liver enzyme and lipid levels. Liver function tests and lipid panels should be performed before starting treatment and at regular intervals during therapy.
If clinically significant deviations are found, the dosage should be adjusted or the treatment discontinued.
Drug Interactions
Isotretinoin interacts with numerous medications including;
- Tetracyclines: Concomitant use of tretinoin and other drugs, such as tetracyclines can lead to an added risk for acute raised intracranial pressure which could result in fatality
- Vitamin A - Supplemental vitamin A can lead to additional toxicity.
- Avoid concomitant use of other Retinoids; may increase skin irritation or hypervitaminosis A.
Conclusion
DescriptionTretiva-5
(ISOTRETINOIN) is used to treat severe, disfiguring nodular acne. Given its
effectiveness in decreasing nodulocystic acne and its ability to prolong the
time interval between remissions, this becomes an attractive alternative for
non-responsive patients. Nevertheless, the medication's substantial side-effect
efficacy obligates prudently selecting patients deploying PCI to treat them
with great soul and proper monitoring. When managed in the right way, Tretiva
5mg can be very advantageous for persons who suffer from extreme acne by really
fixing their pore-clogged skin and also as a result of individuals',
life-resulting to some higher standard quality.
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$10.00
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