Introduction

Super Avana: New Combination ED Medicine It has 1 tablet of Dapoxetine, which is a quantity of 100mg and the other one pill contains Tadalafil which is in an amount of approximately sixty mg. It contains Avanafil 100 mg and Dapoxetine 60 mg. On one hand, Avanafil functions as a PDE5 inhibitor - Dapoxetine also acts as a selective serotonin reuptake inhibitor. This one is going to be dual with the 2 very common erotic dysfunctions together improving both quality and time for erection/ejaculation.

Composition and Mechanism of Action

Avanafil

Pharmacology: Avanafil is a potent and selective inhibitor of the enzyme PDE5 found in corpus cavernosa which degrades cGMP. PDE5 keeps cyclic GMP trapped in smooth muscle cells, and such agonists released are thus used to produce erections. Avanafil inhibits PDE5 to increase the cGMP level producing erection.

Pharmacokinetics: Avanafil is rapidly absorbed, with maximum plasma concentrations within 30-45 minutes. We say this because of its half-life which is approximately 5 hours therefore shorter than the activity duration you might be used to (as opposed to Sildenafil and Tadalafil or other PDE5 inhibitors).

Dapoxetine

Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation, in men lasting with erotic around 2 until they decide to ejaculate. Increases central serotonin activity with SSRI inebriety leads to delayed ejaculation and prolongs time-to-ejaculation(minutes).

Absorption Dapoxetine is rapidly absorbed and the maximum plasma concentration (Cmax) occurs in about 1-2 hours after oral administration. It is short-acting, with a half-life of 1.5 -2 hours; pharmacological properties make it more appropriate for use on-demand rather than daily.

Indications

This specific medication is specifically prescribed for men and contains the following;

• Erectile dysfunction (ED): Inability to maintain an erection long enough for erotic intercourse.
• Premature Ejaculation (PE): The release of semen with a little erotic commencement, sometime before and soon after penetration into the vagina-making trouble to a man or couple.

Dosage and Administration

• Dose: The advised dosage of Super Avana per tab is one tablet absorbed 30 minutes before erotic. You should drink the solution with a full glass of water. The recommended dosing frequency is once per day.
• Administration: Super Avana can be taken with or without food. Click here to learn more about Avanafil's Half-life, a high-fat meal may delay the time of onset of this medicine.

Efficacy

Clinical Studies

Avanafil and Dapoxetine are effective for Erectile Dysfunction {ED} and Premature Ejaculation {PE}, and results of clinical trials have been shown as well. The synergistic effect of the combination Super Avana helps to increase the efficiency and quality of an erection and control ejaculation

Avanafil: Avanafil has a significant effect in improving erectile function as shown by clinical trials. Both the Q1 and head of R&D agreed: Avanafil had a statistically significant effect above placebo in his T2DM [Q4, men], where all readouts were positive for each SGA; men treated with Avanafil reported higher rates of successful intercourse (via diary responses) as well an improved score on the EF domain questions about erection hardness.

Dapoxetine: Randomized trials have shown that Dapoxetine increases intravaginal ejaculation latency time (IELT) when compared with placebo. Men with Dapoxetine had improved control over ejaculation and less personal distress.

Side Effects

Like all medicines, Super Avana can cause side effects. Be mindful of these possible side effects, and consult a healthcare provider if any appear in your case.

Common Side Effects

Avanafil:

• Headache
• Flushing
• Nasal congestion
• Back pain

Dapoxetine:

• Nausea
• Dizziness
• Dry mouth
• Insomnia

Serious Side Effects

Serious side effects are unusual, but in some cases may occur. Symptoms and signs of pregnancy include:

• Priapism: an erection that won't go away (3+ hours) This is a medical emergency that can result in permanent damage.
• You have extreme dizziness or you are fainting: This may suggest that your blood pressure has dropped.
• Changes in vision or hearing: You may also have sudden loss of sight and abrupt effects on your ears. This needs prompt clinical attention as well.
• Hypersensitivity response: Manifestations of an unfavorably susceptible reaction may incorporate skin rash, tingling, or hives on the skin redness; swelling of the face, lips yes gagging and trouble relaxing.

Precautions and Contraindications

Precautions

• Cardiovascular risk: Patients with cardiac failure history should use Super Avana reinforcements. In patients with cardiac diseases, erotic activity has a risk in itself.
• Kidney and Liver Impairment: Dose adjustments may be required for patients with renal or hepatic impairment.
• Other Drugs: Super Avana may interact with other drugs, including nitrates; alpha-blockers; and other PDE5 inhibitors.

Contraindications

• Avoid use of nitrates: With PDE5 inhibitors, it may lead to hypotension; nitrate therapy? Has anyone created an unsafe fall throughout blood pressure?
• Surgery for any liver disease and hypernephroma: Not for being utilized into the patient stricken with this difficulty (Documented) (Super Avana)
• Hypersensitivity: Super Avana is contraindicated in patients with known hypersensitivity to avanafil, dapoxetine, or any of its excipients.