PANGRAF 0.05 MG CAPS
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Introduction
This
Apotex medicine is used to help stop the body from rejecting an organ after a kidney,
liver, or heart transplant; it can only be obtained with a prescription. Belxio)
This medication is a class of drugs called immunosuppressants which reduces the
activity in the immune system and prevents it from attacking the transplanted organ
About PANGRAF 0.05 MG CAPS
Each
PANGRAF 0.05 MG CAPS contains tacrolimus... forests Manomedical dose (mg)
Tacrolimus is a powerful immunosuppressant drug used especially for preventing
transplant rejection. The drug comes in a variety of forms and doses, for this
discussion however, the focus will be on 0.05 mg capsules.
Emphasis will be placed on 0.05 mg capsules
Mechanism of Action
This
increase in cyclosporine could be deadly, as tacrolimus and the closely related
drug NP-113 double blood levels of cyclosporine while increasing two other
known toxic effects by comparable factors: compared to untreated subjects
receiving a given amount of A (cyclosporine), five take those same amounts plus
conventional immune suppression with either FK506 or NP-113. Tacrolimus
inhibits the formation of interleukin-2 (a molecule that promotes activation
and clonal expansion of T-cells) by exposing calcineurin. The immune response
is, in turn, reduced by the inhibition of T-cell activity and this prevents the
body from recognizing that an organ has been transplanted.
Indications and Usage
It
is also used in combined treatment with other immunosuppressants such as
corticosteroids to increase its effectiveness.
Prevention of Organ Rejection
- Liver Transplant; For prevention of the rejection of transplanted liver.
- Kidney Transplant: It is used to prevent the rejection of the kidney after the transplant.
- Heart Transplant Prevents the recipient's body from rejecting a new heart.
Dosage and Administration
The
dose of PANGRAF 0.05 MG CAPS depends on the transplant type, patient's
condition, and co-medications as appropriate They must be used with a properly
prescribed dosage and administration to make sure that the treatment is
effective, while consuming these you are at risk for side effects.
Side Effects
Yes,
although all drugs have side effects they are just useless medicine. If you
know how to manage these side effects well, it might work out.
Common Side Effects
- High blood sugar (hyperglycemia): High doses of TACROLIMUS can increase your blood sugar and cause you to develop diabetes.
- Renal Insufficiency: Poor renal function, creatinine level increased.
- Most likely to Catch Injuries: The immune suppression effects make the patient more susceptible to contracting infections.
- Digestive: Nausea, vomiting (3 times/24 hours), watery diarrhea (starter bolus of fluids for up to 6 liters over 48 hours), or abdominal pain.
- Tremors: Shaking, most often noted in the hands.
Precautions and Warnings
precautions & warning: Pangraf 0.05 mg caps ignore post fields
- Pre-existing Conditions
- Avoid Renal Disease
- For patients with liver damage, dosage may need to be adjusted Liver Failure
- In Appendix: Infections - Use with care in active infection;
Drug Interactions
Tacrolimus
is also used with other medications that interact so, it causes less effectiveness
and more side effects if used tacrolimus.
- Antifungal medications: Drugs (such as ketoconazole and itraconazole can increase levels of tacrolimus
- Antibiotics; Erythromycin is an antibiotic that can raise levels of tacrolimus due to a similar mechanism.
- Mild CYP3A Inhibitors: Calcium Channel Blockers (Diltiazem): Has the potential to inhibit tacrolimus metabolism.
Anticonvulsants
They are received by those in areas of epilepsy Tacrolimus levels decrease
phenytoin and carbamazepine (carba-miXamols) Antitubercular grisea fulvin
decompose its oral Inhibit cyclosporins metabolizing enzyme amplify activity.
Blood Level Monitoring
- Kidney Function: Serial serum creatinine and other
- Hepatic/Renal: Hepatotoxicity may be detected through hepatic function tests.
Conclusion In addition
PANGRAF 0.05 MG CAPS is used to treat the prevention of organ rejection
in transplant patients Knowing how it works, proper dosage recommendations, as
well as potential side effects or necessary precautions that must be taken will
help you safely and effectively use this medication. The periodic monitoring
and follow-up help in the control of treatment, resulting in reduced
complications. Consult with your healthcare professional to get recommendations
that will be tailored according to the variations in treatment.
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$10.00
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$2.75
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