Inhouse product
Mechanism of Action
The active
ingredient in OXYSPAS 2.5 MG is oxybutynin chloride, which is an
anticholinergic agent. It carries out its action by blocking the
muscarinic receptors present in the bladder detrusor muscle. This prevents acetylcholine
from binding to these receptors, which reduces detrusor smooth m
Pharmacokinetics Oxybutynin: is well absorbed from the GI tract. OXYSPAS 2.5 MG PR, being the immediate-release formulation available at Minds Innovation Labs Pvt Ltd portal permits a fast onset of action; generally inside an hour. Distribution Following absorption, oxybutynin is widely distributed in the body and is extensively metabolized by first-pass metabolism to several active and inactive metabolites including N-desethyloxybutynin (HC-45), which has similar pharmacological activity but plasma levels minimally 0.operandsHigher than those found following application of an equative dose as Ditropan tablets. Medium_dose_5.units medium High doses caused blood serum estrogen depression ofscalesGreater lesser infusion in1 over postmenopausal patients with invasive breast cancer.
Metabolism: The drug is extensively metabolized
by the liver, mainly through the cytochrome P450 enzyme system (CYP3A4). Excretion:
Metabolites are mainly eliminated through urine The half-life of oxybutynin is
2-3 hours.
Clinical Applications Indicated in OXYSPAS
2.5 Marination OAB (Overactive Bladder): A condition where symptoms include
urgency, frequency, and incontinence; Neurogenic Bladder: occurs from a spinal
cord injury or neurological disorders when the bladder is not working correctly
Dosage and
Administration Standard
Dosage Adult Dose for OXYSPAS 2.5 MG The usual adult dose of PRODUCT is given
as one tablet two to three times a day. However, the dose may vary based on
individual patient needs and response to treatment. Pediatric Dosage is
typically lower and adjusted to the child's weight and severity of symptoms in
pediatric patients from 5 years old + Special Populations
Side Effects
Reported in Clinical Trials Dry Mouth: The
anticholinergic effects are at least partly responsible for the adverse effect
of dry mouth. Constipation: Decreased contractions in the GI tract can result
in constipation. Blurred Vision: When the ciliary muscle relaxes, it can be
hard to focus on things from afar.
Contraindications
OXYSPAS 2.5 MG is contraindicated in:- Urinary Retention: Predisposing factors for urinary
retention. Imperforate anus: Rare sacral hypertrophy turn Range of motion into
Groin- Shortening concerning contralateral hip joint; Gastric retention
-stomach outlet limitations
Contraindications
Of OXYSPAS 2.5 MGOXYSPAS 2 Urinary Retention:
Delayed Gastric Emptying: For example,
significant gastrointestinal stenoses Acute Narrow-Angle Glaucoma: Due to
the anticholinergic properties of TCA antidepressants. Contraindications Known
hypersensitivity to oxybutynin or its components Drug Interactions Other
Anticholinergics: Co-administration may result in a synergistic increase of the
known anthelminthic side effect profile.
CYP3A4 Inhibitors: (Modest) The therapeutic effect of
Oxybutynin is potentially increased by the inhibition of mediated
metabolism. Alcohol may increase drowsiness or light-headedness!
Conclusion
OXYSPAS
2.5 MG is an effective drug in relieving symptoms of overactive bladder and its
complications Its efficacy in decreasing the frequency of various symptoms
including urinary urgency and incontinence has been well-established, although
its side effects can pose a significant concern for healthcare providers as
their patients must be very cautious when using this medication. Like all
medications, the choice of therapy should be based on what a patient desires
and their actual state so that any benefit gained by being treated outweighs the risks.
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