ARPIZOL 20MG
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Introduction
Overview of ARPIZOL 20MG
Posology ARPIZOL 20MG TABLET is a psychotropic agent indicated:
for the treatment of schizophrenia for the treatment of moderate to severe
manic episodes associated with Bipolar I Disorder Aripiprazole, an
atypical antipsychotic, is unique among these antipsychotic drugs in its
pharmacological profile. Navigating through ingredients and action mechanism to
chemistry and molecular properties, this article is intended to be an
everything-shaded-uncover about ARPIZOL 20MG from what is used for and how should
be an appropriate dosage administration, how it affects its mechanism to side
effects categories to what we all aware as Drug interaction to patient
experience and need for future research in it are written each.
Mechanism of Action
How ARPIZOL 20MG Works in the Body
They
have a different angle of the method in the brain - aripiprazole works through
the dopaminergic and serotonergic pathways. It is classified as a partial
agonist at dopamine D2 receptors - this means that it increases or maintains
the level of normal dopamine production frequently disrupted in mental
illnesses. It may also be viewed as a partial agonist at serotonin 5-HT1A receptors
and an antagonist at 5-HT2A receptors which could contribute to moclobemide's
therapeutic, mood-normalizing, and anti-psychotic properties.
Dosage and Administration
Standard Dosage Guidelines
The initial dose and the recommended maintenance dose of ARPIZOL
20MG depend on the indication for which the patient is being treated:
- Schizophrenia: Typically, 10-15 mg/day, target dose is 15 mg
a day. The clinical response may guide dosing adjustments
- Bipolar disorder Manic and Mixed Episodes:
15 mg once daily may be increased up to 30 mg/day.
- Depressive major: the usual dose is adjuvant therapy as
administration of total dose at night or in divided doses; initially, commonly
experience significant weight gain.
- Irritability associated with autism -- In
podiatric patients, a usual starting dose of 2 mg can be increased to 15 mg per
day
Specific Populations: Women
Dose adjustment may be needed in some patient populations such as:
Elderly Starting doses should be decreased (begin with 5 mg PO
daily) and titrated slowly (at least 4 to 8 weeks) due to increased sensitivity
and risk of AEs.
Hepatic or Renal Impairment: Consider dose adjustments due to
changed drug metabolism and elimination.
Efficacy Studies
Summary of Key Clinical Trials
The effectiveness of ARPIZOL 20MG in the treatment of psychiatric
disorders has been positively confirmed in several clinical trials.
- Schizophrenia - aripiprazole is superior to
placebo in reducing positive and negative symptoms by many randomized
controlled trials.
- Bipolar Disorder: Effective in the treatment of manic
and mixed episodes and for maintaining the prevention of such recurrences
(Placebo-controlled, additional data about the efficacy gap can be found on the
page of the preparation)
- Major Depressive Disorder: Major Depressive disorder treated
with Abilify adjunctive treatment has shown positive effects on 2 cores in the patient group. Behaviors in Adolescents (Mania) Controlled trials have
demonstrated the effectiveness of risperidone; irritability, hostility, and aggressiveness
were statistically significantly improved for both doses.
- Aggression and Irritability (Autism): Clinical
studies have shown statistically significant reductions in irritability and
other related behaviors in pediatric patients.
Comparison with Other Antipsychotic Medications
Table 3 shows several unique features of Aripiprazole due to its various
pharmacologic properties that distinguish it from other antipsychotics.
Lesser risk of Extrapyramidal Symptoms (EPS):
First-generation antipsychotics have got much higher propensity to excite EPS. Less
chance of akathisia, dystonia, or tardive dyskinesia FBDPD Abilify Aripiprazole
Metabolic effect: Aripiprazole induces body weight gain and metabolic parameter
modifications in a lesser magnitude when compared to other atypicals, although
it is on the high half of this spectrum (clozapine, olanzapine,) but not as
severe as with others.
Side-effects and Adverse Reactions
Common Side Effects
Because of its mode of action, ARPIZOL 20MG is commonly associated
with the following Side effects:
- Nausea and Vomiting: And less often, gastrointestinal
disturbances which are usually minor.
- Sleep disturbances: Difficulty falling asleep in some
patients.
- Anxiety - usually worst at the beginning of treatment
- Pain in the head: Common and usually only slightly.
Efficacy, & Safety Effects of Interactions
The pharmacokinetics and pharmacodynamics of aripiprazole are
subject to large interindividual variation and depend largely on the presence
of drug interactions that can be relevant as they can enhance side effects or
reduce therapeutic efficacy. All of the medications that a patient is currently
prescribed should be carefully reviewed with healthcare providers so that
interactions can be managed.
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